Ipamorelin

Ipamorelin is a selective growth hormone secretagogue that works by mimicking ghrelin - the body's natural hunger and GH-release signal. What makes it stand out among GH releasers is selectivity: it triggers meaningful GH release without significantly raising cortisol, prolactin, or hunger, which are the unwanted companions of less targeted GH releasers. This clean profile makes it the most commonly included peptide in GH-focused stacks. Its goal coverage is broad: recovery, muscle building, fat loss, sleep quality, and longevity support. That range, combined with its tolerability, is why it appears in so many protocols as the foundational piece. Ipamorelin is given as a subcutaneous injection of 200-300 mcg, one to three times daily depending on the protocol. Typical timing is before bed and/or after a workout. Unlike some GH secretagogues, it does not strictly require an empty stomach, though timing away from large meals is still reasonable. Courses typically run three to six months. Tolerance is generally very good. The most commonly noted reaction is a mild, brief head-rush sensation around the time of injection - this passes quickly and is not a safety concern for most patients. Like all GH secretagogues, ipamorelin is not appropriate for people with a cancer history. In the US it is available through licensed compounding pharmacies. It pairs well with CJC-1295 (no DAC), tesamorelin, and BPC-157, and is generally not run alongside MK-677. Exact dosing and any stack combinations are determined at your PepDepo consult.