MK-677 (Ibutamoren)

MK-677, also known as Ibutamoren, is an oral ghrelin-receptor agonist that raises both growth hormone and IGF-1 for roughly 24 hours per dose. What distinguishes it from injectable GH secretagogues is its route: it is taken by mouth, which eliminates the injection routine entirely. This makes it appealing to people who want GH-axis support without daily or multiple-daily injections. Its primary goals are muscle building, improving sleep quality, and supporting recovery. Skin health is a secondary benefit, consistent with the role of GH and IGF-1 in tissue maintenance. It tends to be considered by people who prefer an oral protocol or who are not ready for injectable peptides. MK-677 is taken as an oral dose of 10-25 mg once daily, before bed. Courses typically run eight to sixteen weeks. The bedtime timing is preferred because it aligns the GH and IGF-1 pulse with overnight sleep, when natural GH secretion is highest, and because some users find appetite increase and vivid dreams easier to manage during sleep. The main cautions are water retention, increased appetite, and a potential rise in blood sugar. People with diabetes or insulin sensitivity concerns should flag this at consult, as it is something to monitor. Like all GH-axis agents, MK-677 is contraindicated in anyone with a cancer history. Importantly, MK-677 should not be combined with injectable GH secretagogues including sermorelin, ipamorelin, and CJC-1295. It is not an FDA-approved compound and is classified as a research compound in the US. Its evidence base is clinical - there are real human studies behind it. Your licensed provider in the PepDepo network will set the exact dose and monitor relevant labs at consult.