SS-31

SS-31, also known as Elamipretide or MTP-131, is a mitochondrial peptide designed to act directly inside the mitochondria - the energy-producing organelles in every cell. Its mechanism is specific: it binds to cardiolipin, a critical lipid found in the inner mitochondrial membrane, and by doing so it helps restore efficient energy production in mitochondria that have become dysfunctional or inefficient with age, illness, or metabolic stress. The primary goal is energy support, with longevity and recovery as meaningful secondary aims. People most commonly drawn to SS-31 are those experiencing fatigue linked to mitochondrial decline, or those building a broader longevity and healthspan protocol. SS-31 is currently in clinical trials for mitochondrial disease, which places it a step beyond purely preclinical compounds - though it is still classified as investigational and not yet FDA-approved for general use. It is taken by subcutaneous (SC) injection in the morning. Frequency is daily or several times weekly, and cycles typically run 4 to 8 weeks. It stacks well with MOTS-c and NAD+ for broader mitochondrial support. There are no exclusion flags based on pregnancy or cancer history. Because it is investigational, all use is under clinician supervision. Exact dosing is set with a licensed provider in the PepDepo network at consult.